1.Explain in your own words why increasing the hydrophobicity of a drug leads to "entropic optimization" of the binding affinity. Please consider all of the entropic changes that occur in drug binding and how they alter affinity.
2.What are the limitations of this approach to affinity optimization?
3.Please identify some other examples of the practical application of the entropy/enthalpy compensation principle.
This question was answered on: Sep 16, 2020
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