Question Details

(Solved) (Latest ver. Aug 2020) - Biochemical activity of Malate dehydrogenase

Brief item decscription

Item details:


The following questions refer to the mitochondrial enzyme MALATE DEHYDROGENASE.

What is the chemical reaction, within the citric acid cycle, that is catalyzed by malate dehydrogenase, and which substrates, products, and/or cofactors are involved?

The reaction from the previous question is classified as a dehydrogenation, which means that the reaction represents a(n) _______________ wherein ________________.

a. oxidation reaction; malate loses electron(s)
b. oxidation reaction; malate gains electron(s)
c. reduction reaction; malate loses electron(s)
d. reduction reaction; malate gains electron(s)
e. hydrolysis reaction; malate loses hydrogen(s)

The ΔG'° for the chemical reaction catalyzed by malate dehydrogenase is +29.7 kJ/mol. Under standard biochemical conditions, is this reaction exergonic, endergonic, or close to equilibrium? Under these conditions, in which direction would this chemical reaction be expected to proceed?

Under typical cellular conditions of glycolysis and the citric acid cycle, does the malate dehydrogenase reaction represent a reversible catalytic step or an essentially irreversible step? Based on this answer, is the actual ΔG expected to be greater than, less than, or about equal to the ΔG'°? Why?

Within the context of the citric acid cycle the dehydrogenation of malate proceeds to the right (i.e. formation of oxaloacetate is favored). Why is this is so, and what other reactions or substrates/products of the TCA cycle are important here?

When gluconeogenesis is favored (and glycolysis is downregulated), describe the chemical reaction that is catalyzed by malate dehydrogenase. Under such conditions, is the formation of oxaloacetate or malate favored? Explain why the reaction proceeds in the direction you describe.


About this question:

This question was answered on: Sep 16, 2020

PRICE: $11.5 (18.37 KB)

Buy this answer for only: $11.5

Pay using PayPal (No PayPal account Required) or your credit card. All your purchases are securely protected by PayPal.

Need a similar solution fast, written anew from scratch? Place your own custom order

We have top-notch tutors who can help you with your essay at a reasonable cost and then you can simply use that essay as a template to build your own arguments. This we believe is a better way of understanding a problem and makes use of the efficiency of time of the student. New solution orders are original solutions and precise to your writing instruction requirements. Place a New Order using the button below.

Order Now